Mycobacterial glycolipids in host responses against tuberculosis
نویسندگان
چکیده
منابع مشابه
Distribution, Characterization of Mycobacterial Glycolipids and Host Responses
Robert Koch discovered the acid-fast bacterium that is the pathogenic germ of tuberculosis (TB) in 1882 [1]. TB is a major public health problem in the world and the leading cause of death from a single infectious agent. The World Health Organization estimates that one third of the world’s population is infected with Mycobacterium tuberculosis, and annually reports the global burden of the dise...
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Mycobacteria elaborate a great variety of glycolipids of rather exotic structure. Some of these lipids are abundant cell envelope components and are exposed on the bacterial surface. These comprise the species-specific phenolic glycolipids, glycopeptidolipids, sulfatides, and lipooligosaccharides, and the ubiquitous phosphatidylinositolmannosides. Because pathogenic mycobacterial species are fa...
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Tuberculosis (TB) caused by the intracellular pathogen, Mycobacterium tuberculosis (Mtb), claims more than 1.5 million lives worldwide annually. Despite promulgation of multipronged strategies to prevent and control TB, there is no significant downfall occurring in the number of new cases, and adding to this is the relapse of the disease due to the emergence of antibiotic resistance and the abi...
متن کاملHumoral immune response against mycobacterial antigens in children with tuberculosis.
Different clinical outcomes of tuberculosis (TB) are related to the balance between cell-mediated and humoral immunity and may depend on environmental and individual factors including age and sex. The purpose of this study was to analyze the humoral immune response to recombinant and native mycobacterial antigens in relation to clinical presentations of pulmonary TB in children. We examined 224...
متن کاملDNA encoding individual mycobacterial antigens protects mice against tuberculosis.
Over the last few years, some of our experiments in which mycobacterial antigens were presented to the immune system as if they were viral antigens have had a significant impact on our understanding of protective immunity against tuberculosis. They have also markedly enhanced the prospects for new vaccines. We now know that individual mycobacterial protein antigens can confer protection equal t...
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ژورنال
عنوان ژورنال: Ensho Saisei
سال: 2001
ISSN: 1346-8022,1880-5795
DOI: 10.2492/jsir.21.133